Advancing Pediatric Drug Development

Steroid-resistant acute graft-versus-host disease in pediatric populations

Briefly describe your research question :

In steroid-resistant graft versus host disease, what are the expected distributions of main characteristics (age, underlying disease, aGvHD grade and organs affected, source of the graft, graft compatibility, type of conditioning regimen, distribution of steroid-resistance ... ) ? Which ones differ importantly from the adult population ?

Some characteristics are known to differ between age groups in aGvHD, such as the underlying disease. Do other characteristics of this disease and how it is treated also vary between pediatric, adolescent and adult populations? If yes, do they correlate with age, or with the underlying disease, or neither ?

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Idea No. 186