Advancing Pediatric Drug Development

Risk of osteonecrosis and bone fractures with long-term use of proton-pump inhibitors

Briefly describe your research question :

Is the long-term use of proton-pump inhibitors associated with an increased risk of bone fractures, osteonecrosis (or even growth delay) in children?  If so, what are the primary determinants of risk?  For example: CYP2D6 metabolizer status, concomitant use of high-dose corticosteroids, age of onset, duration of use, other disease states/comorbidities?  


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1 vote
Idea No. 157