Advancing Pediatric Drug Development

Risk of osteonecrosis and bone fractures with long-term use of proton-pump inhibitors trending idea

Briefly describe your research question :

Is the long-term use of proton-pump inhibitors associated with an increased risk of bone fractures, osteonecrosis (or even growth delay) in children?  If so, what are the primary determinants of risk?  For example: CYP2D6 metabolizer status, concomitant use of high-dose corticosteroids, age of onset, duration of use, other disease states/comorbidities?  

 

See also: 

https://pubmed.ncbi.nlm.nih.gov/31175146/ 

https://pubmed.ncbi.nlm.nih.gov/32176276/

https://pubmed.ncbi.nlm.nih.gov/25986385/

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Idea No. 157