Advancing Pediatric Drug Development

Longitudinal natural history of pediatric disease

Briefly describe your research question :

Can the pooled databases be used to better understand the longitudinal natural history of pediatric disease states such as Nonalcoholic fatty liver disease (NAFLD), including differences between pediatric and adult onset, pathophysiology, mechanism and disease progression/long term sequelae?

• Considering the recently published paper on the long term complications observed in the TODAY study, long term cardiovascular impact is of particular interest in the pediatric T2DM population. What does the FDA pooled database add to this understanding?

• What is the impact of pubertal insulin resistance on the efficacy of T2DM drugs?

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Idea No. 207