Advancing Pediatric Drug Development

Intranasal Antipyretic development in Pediatric Poulation Edited

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Pediatric patients with Respiratory illnesses generally arrive to the hospital with high fevers and quite irritable. During this time their respiratory rate and work of breathing often looks much worse until the fever is controlled and mild analgesia is established.  If normothermia can be maintained at home quickly via the use of an intranasal option, these patients may not progress in illness past the tipping point of needing higher intervention/ hospitalization. Often times we hear parents describe attempts to give oral medication, but the infants will either be too upset to take it, or they have an emesis before it absorbs. The barriers for rectal delivery are also parents apprehension, excretion prior to absorption.  If intranasal anypyretic use can be established in the pediatric setting and prove fast acting, then it could be a valuable tool for parents and pediatric healthcare providers.

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Idea No. 126