Current there is no cure for biliary atresia other than liver transplantation. From the current clinical studies world wide, we believe that targeting liver fibrosis and cirrhosis will ultimately help those children with this rare disease. And such treatment could be expanded to the general population for any cause related liver cirrhosis.
Our preliminary research has found out that targeting TGF-beta and IL-2 combined with anti-MMP enzyme could work together to inhibit fibrosis and revert the liver fibrosis in children with Biliary atresia and after Kasai procedure. Do you see targeting these two pathway working together to further reverse the liver fibrosis? or at least such approach is reasonable for the associated liver fibrosis of this disease?